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Cold or allergy medicine, sedatives, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression or anxiety can add to sleepiness caused by Pramipexole. Tell your doctor if you regularly use any of these medicines, or any other medicines for Parkinson's disease.

Tell your doctor about all other medicines you use, especially:

  • amantadine (Symmetrel);
  • cimetidine (Tagamet);
  • diltiazem (Cardizem, Cartia, Dilacor, Tiazac);
  • ranitidine (Zantac);
  • quinidine (Quin-G);
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  • medicine to prevent or treat nausea and vomiting, such as metoclopramide (Reglan, Metozolv) or promethazine (Pentazine, Phenergan, Anergan, Antinaus); or
  • medicine to treat psychiatric disorders, such as chlorpromazine (Thorazine), fluphenazine (Permitil, Prolixin), haloperidol (Haldol), thiothixene (Navane), thioridazine (Mellaril), and others.

This list is not complete and other drugs may interact with Pramipexole. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

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